This analysis aimed to (a) explore whether baseline cognitive measures could predict response to Deep Brain Stimulation (DBS) of the subcallosal cingulate gyrus for treatment-resistant depression (TRD), and (b) compare neurocognitive performance prior to and 12 months after DBS implantation. These preliminary results suggest that psychomotor speed may be a useful baseline predictor of SCG DBS treatment response, and support previous suggestions that SCG DBS has no deleterious effects on cognition.