Fatigue

Fatigue in Patients with Major Depressive Disorder: Prevalence, Burden and Pharmacological Approaches to Management

Fatigue is a frequently occurring symptom in Major Depressive Disorder (MDD), reported by over 90% of individuals with MDD. In this paper, we presented an overview of the epidemiology, burden, and functional impact of fatigue. We also reviewed the literature on pharmacological approaches to managing fatigue, finding that medications affecting dopamine and/or norepinephrine were most effective.