Depression

This report from the CAN-BIND-1 study found that clinical response to the SSRI escitalopram was associated with clinical and neuroimaging correlates of reward processing.

This literature review sought to elucidate the clinical and neurobiological differences in anhedonia and reward processing between MDD and schizophrenia, and explore the challenges and benefits of assessing anhedonia as a transdiagnostic feature under the Research Domain Criteria (RDoC) framework.

Fatigue is a frequently occurring symptom in Major Depressive Disorder (MDD), reported by over 90% of individuals with MDD. In this paper, we presented an overview of the epidemiology, burden, and functional impact of fatigue. We also reviewed the literature on pharmacological approaches to managing fatigue, finding that medications affecting dopamine and/or norepinephrine were most effective.