Amanda Ceniti, PhD

Amanda Ceniti, PhD

(she/her/hers)
hear my name

Assistant Instructional Professor

University of Chicago

About Me

Hello! I am an Assistant Instructional Professor of Psychology in the Master of Arts Program in the Social Sciences (MAPSS) at the University of Chicago. I hold a PhD from the Institute of Medical Science and the Collaborative Program in Neuroscience at the University of Toronto, where I also received an HBSc in Human Biology: Neuroscience. Prior to joining the University of Chicago, I was a Postdoctoral Fellow at the ASR Suicide & Depression Studies Program at St. Michael’s Hospital and the University of Toronto.

My research focuses on depression and suicide risk using interdisciplinary methods, including neuroimaging, cognitive tasks, clinical measures, and qualitative interviews. My current work focuses on the needs of family and friends supporting their loved ones at risk of suicide. There is a significant lack of resources available for this group and a strong need to bolster community-level suicide prevention strategies. In my postdoctoral work with Drs. Sakina Rizvi and Yvonne Bergmans, I co-led a national needs assessment to understand the barriers and gaps experienced by friends/family in supporting their loved ones, using qualitative and participatory action research methods. We are now using these findings to co-develop and test a novel suicide prevention training program specific to friend/family needs, in partnership with people with lived/living experience.

My doctoral research in neuroscience with Dr. Sidney Kennedy focused on the association between Major Depressive Disorder and mild traumatic brain injury (mTBI), with a particular focus on the brain’s reward system. In this work, I used resting-state and task-based neuroimaging (fMRI); behavioral measures of reward and cognition; and clinical interviews and questionnaires to better understand the cumulative impact of mTBI and depression, compared to either condition alone. I have also studied the effects of the COVID-19 pandemic on mental health, including trends in emergency department visits for self-harm during COVID-19 as well as patient and provider experiences with virtual mental health care. A final area of research focus involves cognitive and neuroimaging predictors of treatment response in depression, including to pharmacotherapy and neurostimulation.

In addition to my research and teaching, I am also involved with public engagement and knowledge translation activities, including coordination of the national Storybook Project initiative, a published collection of personal stories written by those impacted by suicide across Canada.

Interests

  • Depression & suicide risk
  • Community-based suicide prevention
  • Functional neuroimaging
  • Neuropsychiatric impact of traumatic brain injury
  • Mental health public outreach & advocacy

Education

  • PhD in Medical Science, 2022

    University of Toronto

  • HBSc in Human Biology (Neuroscience), 2015

    University of Toronto

Skills

Neuroimaging

Analysis of functional MRI data

Clinical Trials

Coordination of industry-sponsored & investigator-initiated depression trials

Knowledge Translation

Mental health outreach & advocacy

Recent Publications

FDG-PET as a pre-operative biomarker for predicting and optimizing response to subcallosal cingulate area deep brain stimulation

Background: Deep brain stimulation targeting the subcallosal cingulate area (SCC-DBS) has emerged as a promising therapy for …

Lack of neuropsychological effects following short-term subcallosal cingulate gyrus deep brain stimulation in treatment-resistant depression: a randomised crossover study

Background: The subcallosal cingulate gyrus (SCG) is integral to cognitive function and mood regulation. Open-label SCG deep brain …

An empirical analysis of structural neuroimaging profiles in a staging model of depression

We examine structural brain characteristics across three diagnostic categories: at risk for serious mental illness; first-presenting …

Self-Harm Presentations to Hospital Trauma Centre Emergency Departments during the First Year of the COVID-19 Pandemic

The COVID-19 pandemic raised concerns regarding increased suicide-related behaviours. This study compared characteristics and counts of Emergency Department (ED) presentations for self-harm at three Toronto hospitals during vs. prior to the pandemic’s first year. While the number of self-harm presentations to these trauma centres did not increase during the early pandemic, their proportion of total presentations was increased. Intra-pandemic self-harm was associated with variables indicating medically severe injury, economic stressors, and being widowed, which may inform future suicide- and self-harm prevention strategies.

Resting-state neural mechanisms of capability for suicide and their interaction with pain – A CAN-BIND-05 Study

Background: Suicidal ideation is highly prevalent in Major Depressive Disorder (MDD). However, the factors determining who will …

Teaching

Course Instructor: Reward and Motivation (MAPS 31705)

Why do we crave social media likes, persist in pursuing ambitious goals, or struggle with motivation during challenging times? Drawing on findings from psychology and neuroscience, this course will provide a comprehensive overview of the brain’s reward system. Students will become familiar with historical and current theoretical constructs of reward, including facets of motivation, anticipation, and pleasure, as well as their underlying neurobiology. We will understand the diverse experimental approaches that can be used to study reward function, including animal models, task-based neuroimaging (fMRI), computerized behavioral tasks, and clinical questionnaires. We will also discuss how the reward system is differentially affected in mental health conditions such as depression and substance use disorders, and the emerging interest in using reward as a biomarker and treatment target. Finally, we will explore the real-world applications of these findings, including on productivity, social media usage, education, and public policy.

Course Instructor: More than Mood: Biopsychosocial Approaches to Depression (MAPS 36405)

Depression is a common mental health condition that is a leading cause of disability worldwide. Using a biopsychosocial lens, this course will discuss the etiology, presentation, and treatment of this condition with a focus on clinical research principles and experimental design. Students will become familiar with relevant neurotransmitter systems and brain structure/function; psychological and cognitive correlates; and social and cultural contributors. We will discuss the substantial heterogeneity of depression, as well as recent efforts in precision psychiatry to identify more homogenous subtypes using ‘big data’. Finally, students will become familiar with current and emerging treatment strategies, including pharmacotherapy, psychotherapy, neurostimulation, and social interventions. By using depression as a case study, students will deepen their ability to critically read and evaluate scientific articles, craft novel research questions, and apply a biopsychosocial lens to other constructs.

Course Instructor: Survey Research Methods in Psychology (MAPS 36036)

How do we distil complex constructs of human behavior like personality and resilience into brief survey measures? How do the questions we ask shape the responses we receive? Drawing on examples from psychology and health research, this course will examine the nuanced process of developing and validating high-quality survey measures. Specific attention will be paid to validity, question order effects and wording, cross-cultural considerations, sampling methods, and psychological and social phenomena that may influence participant responses. We will discuss common issues in psychology survey design and data collection, as well as strategies to mitigate bias, error, and missing data. Through practical workshops using electronic data capture tools, students will also gain hands-on experience building surveys and collecting, analyzing, and interpreting their own data.

Course Instructor: Perspectives in Social Science Analysis (MAPS 30000)

Perspectives in Social Science Analysis is an introduction to interdisciplinary social theory which aims to teach you how to read social science research at the graduate level and develop your ability to formulate and execute a successful master’s thesis.

Guest Lecturer: Depression, Concussion, & Suicide Prevention: My Journey in Clinical Research & Outreach

Guest Lecturer: Mental Health Perspectives: Inflammation and Microbiome

Teaching Assistant, Topics in Health & Disease (3rd Year Undergraduate)

Teaching Assistant, Topics in Health & Disease (3rd Year Undergraduate)

Teaching Assistant, Topics in Health & Disease (3rd Year Undergraduate)

Teaching Assistant, Topics in Health & Disease (3rd Year Undergraduate)

Teaching Assistant, Intro to Neuroscience (2nd Year Undergraduate)

Teaching Assistant, Topics in Health & Disease (3rd Year Undergraduate)

Outreach

FIRST Program Study Info Session with Roots of Hope Nova Scotia

June 20, 2023 — Had the opportunity to speak with community members about our ongoing research project to build support capacity among the friends/family of those at risk of suicide, in a virtual session hosted by Roots of Hope Nova Scotia.

CAN-BIND Podcast - Canadian Virtual Mental Health Care

June 2, 2022 — Participated as a guest on Episode 8 of the CAN-BIND Podcast, discussing the findings of our recent study on remote mental health care during COVID-19.

Storybook Project Virtual Book Launch

Sept. 10, 2021 — Virtual book launch event held on World Suicide Prevention Day 2021, sharing our book of stories by those touched by suicide.

Keenan Popular Science Lecture

Feb. 13, 2020 — Public talk at St. Michael’s Hospital to high school students about suicide prevention and how to have a conversation if you’re concerned about someone.

World Suicide Prevention Day 2019

Sept. 10, 2019 — Featured video interview for WSPD 2019 about the ASR Program’s Storybook Project outreach initiative, in the context of my personal experience with suicide loss.

Training

Advanced University Teaching Preparation Certificate Program

This 2-year certificate program is geared toward graduate students interested in teaching in higher education, and included ten workshops on topics ranging from accessibility and educational technologies to community engagement and equity and inclusion in teaching. Also included in the program were two teaching practicum sessions, and the opportunity to prepare a teaching dossier and receive feedback.